Article

Microtubule-Connexin-43 regulation suppresses arrhythmias and fibrosis in Duchenne muscular dystrophy mice

2022-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Dilated cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD) patients due to advancements in skeletal muscle therapies yet limited presence of cardiac treatments. The phosphorylation status of gap junction protein Connexin-43 (Cx43) drives Cx43 remodeling and the development of arrhythmias and fibrosis. Based on evidence that Colchicine drug treatment improves Cx43 p...

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Literature Corpus work: 14084fe3-486f-5a29-8d33-34747a42b628
DOI: 10.1101/2022.03.29.486276

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