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Article

Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2012

Shahpasand Kourosh, Uemura Isao, Saito Taro, Asano Tsunaki, Hata Kenji, Shibata Keitaro, Toyoshima Yoko, Hasegawa Masato, Hisanaga Shin-Ichi

Abstract excerpt

The microtubule-associated protein Tau is a major component of the neurofibrillary tangles that serve as a neuropathological hallmark of Alzheimer's disease. Tau is a substrate for protein phosphorylation at multiple sites and occurs in tangles in a hyperphosphorylated state. However, the physiological functions of Tau phosphorylation or how it may contribute mechanistically to Alzheimer's pathophysiology are not...

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PMID: 22396417
DOI: 10.1523/JNEUROSCI.5927-11.2012
PMCID: PMC6621814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease.PMID 22396417Read ↗

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