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Article

A molecular and structural mechanism for G protein-mediated microtubule destabilization.

The Journal of biological chemistry - 11 Feb 2011

Davé Rahul H, Saengsawang Witchuda, Lopus Manu, Davé Sonya, Wilson Leslie, Rasenick Mark M

Abstract excerpt

The heterotrimeric, G protein-coupled receptor-associated G protein, Gα(s), binds tubulin with nanomolar affinity and disrupts microtubules in cells and in vitro. Here we determine that the activated form of Gα(s) binds tubulin with a K(D) of 100 nm, stimulates tubulin GTPase, and promotes microt...

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Identifiers

PMID: 21112971
DOI: 10.1074/jbc.M110.196436
PMCID: PMC3039364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21112971-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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