Article
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.
The Biochemical journal - 1 Jun 1996
Litersky J M, Johnson G V, Jakes R, Goedert M, Lee M, Seubert P
Abstract excerpt
Phosphorylation of tau protein at Ser-262 has been shown to diminish its ability to bind to taxol-stabilized microtubules. The paired helical filaments (PHFs) found in Alzheimer's disease brain are composed of PHF-tau, which is hyperphosphorylated at multiple sites including Ser-262. However, protein kinase(s) able to phosphorylate this site are still under investigation. In this study, the ability of cyclic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.