Article
Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis.
Gastroenterology - 1 Jul 2010
Czaja Albert J, Manns Michael P
Abstract excerpt
Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, interface hepatitis (based on histologic examination), hypergammaglobulinemia, and production of autoantibodies. Many clinical and basic science studies have provided important insights into the pathogenesis and treatment of AIH. Transgenic mice that express human antigens and develop autoantibodies, liver-infiltrating CD4(+) T...
Topics
- Animals
- Autoantigens
- Biomarkers
- Disease Models, Animal
- Hepatitis, Autoimmune
- Humans
- Mice
- Molecular Mimicry
- Phenotype
- Recurrence
- Salvage Therapy
- T-Lymphocytes, Regulatory