Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2003

Schramm Christoph, Protschka Martina, Köhler Heinz H, Podlech Jürgen, Reddehase Matthias J, Schirmacher Peter, Galle Peter R, Lohse Ansgar W, Blessing Manfred

Abstract excerpt

In autoimmune hepatitis, strong TGF-beta1 expression is found in the inflamed liver. TGF-beta overexpression may be part of a regulatory immune response attempting to suppress autoreactive T cells. To test this hypothesis, we determined whether impairment of TGF-beta signaling in T cells leads to increased susceptibility to experimental autoimmune hepatitis (EAH). Transgenic mice of strain FVB/N were generated...

Topics

Join the communities discussing this publication.

B-Lymphocytes
Blotting, Northern
Enzyme-Linked Immunosorbent Assay
Hepatitis, Autoimmune
Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutrophil Infiltration

Transforming Growth Factor beta

Source

Identifiers

PMID: 12466145
DOI: 10.1152/ajpgi.00286.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice.PMID 12466145Read ↗

Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis.Semantic proximity Read ↗

Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis.Semantic proximity Read ↗

Anti-Mitochondrial Antibodies and Primary Biliary Cirrhosis in TGF-β Receptor II Dominant-Negative MiceSemantic proximity Read ↗

Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells.Semantic proximity Read ↗

Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models.Semantic proximity Read ↗

Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development.Semantic proximity Read ↗

Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis.Semantic proximity Read ↗

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.Semantic proximity Read ↗

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.Semantic proximity Read ↗

Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.Semantic proximity Read ↗

Murine models of autoimmune cholangitisSemantic proximity Read ↗

Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.