Article
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.
Nature structural & molecular biology - 1 Jul 2009
Jacob Yannick, Feng Suhua, LeBlanc Chantal A, Bernatavichute Yana V, Stroud Hume, Cokus Shawn, Johnson Lianna M, Pellegrini Matteo, Jacobsen Steven E, Michaels Scott D
Abstract excerpt
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1). The enzymes catalyzing DNA methylation and H3K9me2 have been identified; alterations in these proteins lead to reactivation of silenced heterochromatic elements. The enzymes responsible for...
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