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Article

Large-scale heterochromatin remodeling linked to overreplication-associated DNA damage.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2017

Feng Wei, Hale Christopher J, Over Ryan S, Cokus Shawn J, Jacobsen Steven E, Michaels Scott D

Abstract excerpt

Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in the overreplication of heterochromatin. Here we show that the overreplication results in DNA damage and extensive chromocenter remodeling into unique structures we have named "overreplication-associated centers" (RACs). RACs have a highly ordered...

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Identifiers

PMID: 28028228
DOI: 10.1073/pnas.1619774114
PMCID: PMC5240675

Genes

ATM
ATR
RAD51

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