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Article

DNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis.

PLoS genetics - 1 Jul 2012

Stroud Hume, Hale Christopher J, Feng Suhua, Caro Elena, Jacob Yannick, Michaels Scott D, Jacobsen Steven E

Abstract excerpt

The relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutations of the H3K27 methyltransferase genes, Arabidopsis trithorax-related protein5 (ATXR5) and ATXR6, result in re-replication (repeated origin firing within the same cell cycle). Here we show that mutations that reduce DNA methylation act to suppress the re-replication phenotype of atxr5 atxr6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22792077
DOI: 10.1371/journal.pgen.1002808
PMCID: PMC3390372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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