Article
A role for RNAi in the selective correction of DNA methylation defects.
Science (New York, N.Y.) - 20 Mar 2009
Teixeira Felipe Karam, Heredia Fabiana, Sarazin Alexis, Roudier François, Boccara Martine, Ciaudo Constance, Cruaud Corinne, Poulain Julie, Berdasco Maria, Fraga Mario F, Voinnet Olivier, Wincker Patrick, Esteller Manel, Colot Vincent
Abstract excerpt
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, which suggests that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis (as in cancer) or meiosis, leading to epiallelic variation. We demonstrated the existence of an efficient mechanism that protects against transgenerational loss of...
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