The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.

doi:10.1073/pnas.2115570119

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Article

The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2022

Potok Magdalena E, Zhong Zhenhui, Picard Colette L, Liu Qikun, Do Truman, Jacobsen Cassidy E, Sakr Ocean, Naranbaatar Bilguudei, Thilakaratne Ruwan, Khnkoyan Zhanna, Purl Megan, Cheng Harrison, Vervaet Helena, Feng Suhua, Rayatpisheh Shima, Wohlschlegel James A, O'Malley Ronan C, Ecker Joseph R, Jacobsen Steven E

Abstract excerpt

ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) AND ATXR6 are required for the deposition of H3K27me1 and for maintaining genomic stability in Arabidopsis Reduction of ATXR5/6 activity results in activation of DNA damage response genes, along with tissue-specific derepression of transposable elements (TEs), chromocenter decompaction, and genomic instability characterized by accumulation of excess DNA from...

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PMID: 35027454
DOI: 10.1073/pnas.2115570119
PMCID: PMC8784105

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