Article
A 5' extended IFN-stimulating response element is crucial for IFN-gamma-induced tripartite motif 22 expression via interaction with IFN regulatory factor-1.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010
Gao Bo, Wang Yaxin, Xu Wei, Duan Zhijian, Xiong Sidong
Abstract excerpt
Interferon-gamma is crucial for the noncytopathic clearance of hepatitis B virus. In our previous study, we demonstrated that an IFN-gamma-inducible molecule, tripartite motif (TRIM) 22, played an important role in antiviral immunity against hepatitis B virus. However, the molecular mechanism of TRIM22 induction by IFN-gamma is still unclear. In this study, we identified a novel cis-element termed 5' extended...
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