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Article

TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction

3 Apr 2021

Abstract excerpt

The type I interferon (IFN-I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely associated with autoimmune diseases. TRIM10 dysfunction may be associated closely with certain autoimmune disorders. Here, we observed that the serum TRIM10 protein level is lower in patients with systemic lupus erythematosus than in healthy control subjects. We...

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PMID: 33811647
DOI: 10.1002/eji.202049073

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