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Article

TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

30 Aug 2022

Abstract excerpt

BACKGROUND: Recognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression of a group of genes known as IFN-I-stimulated genes (ISGs) to block viral infection. The tripartite motif containing 22 (TRIM22) is an ISG with strong antiviral functions. RESULTS: Here we have...

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PMID: 36042495
DOI: 10.1186/s13578-022-00872-w

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