Article
Functional complementation of ataxia-telangiectasia group D (AT-D) cells by microcell-mediated chromosome transfer and mapping of the AT-D locus to the region 11q22-23.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Lambert C, Schultz R A, Smith M, Wagner-McPherson C, McDaniel L D, Donlon T, Stanbridge E J, Friedberg E C
Abstract excerpt
The hereditary human disease ataxia-telangiectasia (AT) is characterized by phenotypic complexity at the cellular level. We show that multiple mutant phenotypes of immortalized AT cells from genetic complementation group D (AT-D) are corrected after the introduction of a single human chromosome from a human-mouse hybrid line by microcell-mediated chromosome transfer. This chromosome is cytogenetically abnormal....
Topics
- Ataxia Telangiectasia
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA Damage
- DNA Repair
- Genetic Complementation Test
- Humans
- Hybrid Cells
- In Vitro Techniques
- Karyotyping