Article
Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells.
International journal of radiation biology - 1 Dec 1994
Zdzienicka M Z, Verhaegh G W, Jongmans W, Morolli B, Jaspers N G, Oshimura M
Abstract excerpt
In order to isolate a human gene complementing the defect in A-T-like hamster cell mutants, the mutants were used as recipients for genomic DNA transfection, using either HeLa chromosomal DNA or DNA from a human cosmid library. Three primary transformants with an intermediate X-ray sensitivity an...
Topics
- Animals
- Ataxia Telangiectasia
- CHO Cells
- Cricetinae
- DNA, Complementary
- Disease Models, Animal
- Gene Transfer Techniques
- Genetic Complementation Test
- HeLa Cells
- Humans
- Mice
- Mutation
- Radiation Tolerance
- Transfection
- Transformation, Genetic
- X-Rays