Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells.

International journal of radiation biology - 1 Dec 1994

Zdzienicka M Z, Verhaegh G W, Jongmans W, Morolli B, Jaspers N G, Oshimura M

Abstract excerpt

In order to isolate a human gene complementing the defect in A-T-like hamster cell mutants, the mutants were used as recipients for genomic DNA transfection, using either HeLa chromosomal DNA or DNA from a human cosmid library. Three primary transformants with an intermediate X-ray sensitivity and almost normal sensitivity to MMS, but retaining radioresistant DNA synthesis (RDS), were obtained. To identify the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cricetinae
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Genetic Complementation Test

Share to HeLa Cells

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 7836847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells.PMID 7836847Read ↗

Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.Semantic proximity Read ↗

Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation.Semantic proximity Read ↗

Cellular characteristics of Chinese hamster cell mutants resembling ataxia telangiectasia cells.Semantic proximity Read ↗

Functional complementation of a genetic deficiency with human artificial chromosomes.Semantic proximity Read ↗

The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes.Semantic proximity Read ↗

Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.Semantic proximity Read ↗

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells.Semantic proximity Read ↗

Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants.Semantic proximity Read ↗

Characterization of Chinese hamster cell lines that are x-ray-sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.Semantic proximity Read ↗

Functional complementation of ataxia-telangiectasia group D (AT-D) cells by microcell-mediated chromosome transfer and mapping of the AT-D locus to the region 11q22-23.Semantic proximity Read ↗

Chinese hamster cells meet DNA repair: an entirely acceptable affair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.