Article
Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein.
Mutagenesis - 1 Mar 2000
Tauchi H, Green C, Knapp M, Laderoute K, Kapp L
Abstract excerpt
The ATDC gene was cloned using functional complementation and complements the radiosensitivity of ataxia telangiectasia (AT) group D cells. Although a number of transcripts have been detected, only a 3.0 kb cDNA found in a HeLa cell cDNA library has been cloned. Since AT group D cells express only a 2.4 kb transcript, efforts were made to clone and sequence this transcript. Using a biotinylated oligonucleotide...
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