Article
Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants.
Human genetics - 1 Oct 1993
Jongmans W, Wiegant J, Oshimura M, James M R, Lohman P H, Zdzienicka M Z
Abstract excerpt
It has been shown that the X-ray-sensitive Chinese hamster V79 mutants (V-E5, V-C4 and V-G8) are similar to ataxia-telangiectasia (A-T) cells. To determine whether the AT-like rodent cell mutants are defective in the gene homologous to A-T (group A, C or D), human chromosome 11 was introduced to...
Topics
- Animals
- Ataxia Telangiectasia
- Cell Survival
- Chromosomes, Human, Pair 11
- Cricetinae
- Cricetulus
- Genetic Complementation Test
- Genotype
- Humans
- Hybrid Cells
- In Situ Hybridization, Fluorescence
- Phenotype
- Polymerase Chain Reaction
- Radiation Tolerance
- Sequence Homology, Nucleic Acid
- Streptonigrin
- Transfection