Article
Increased mutagenesis and unique mutation signature associated with mitotic gene conversion.
Science (New York, N.Y.) - 2 Jul 2010
Hicks Wade M, Kim Minlee, Haber James E
Abstract excerpt
To examine the fidelity of DNA synthesis during double-strand break (DSB) repair in Saccharomyces cerevisiae we studied gene conversion in which both strands of DNA are newly synthesized. The mutation rate increases up to 1400 times over spontaneous events, with a significantly different mutation signature. Especially prominent are microhomology-mediated template switches. Recombination-induced mutations are...
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