Article
Low-fidelity DNA synthesis by human DNA polymerase theta.
Nucleic acids research - 1 Jun 2008
Arana Mercedes E, Seki Mineaki, Wood Richard D, Rogozin Igor B, Kunkel Thomas A
Abstract excerpt
Human DNA polymerase theta (pol or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol may synthesize DNA with low fidelity. Here, we show that when copying undamaged DNA, pol generates single base errors at rates 10- to more than 100-fold higher...
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