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Article

Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

The Journal of allergy and clinical immunology - 1 Aug 2010

Sun Xiaoguang, Ma Shwu-Fan, Wade Michael S, Flores Carlos, Pino-Yanes Maria, Moitra Jaideep, Ober Carole, Kittles Rick, Husain Aliya N, Ford Jean G, Garcia Joe G N

Abstract excerpt

BACKGROUND: The genetic mechanisms underlying asthma remain unclear. Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation. OBJECTIVE: We explored the contribution of polymorphisms in the S1PR1 gene to asthma susceptibility. METHODS: A combination of...

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Identifiers

PMID: 20624651
DOI: 10.1016/j.jaci.2010.04.036
PMCID: PMC3495167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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