Article

Sphingosine-1-phosphate – sphinganine-1-phosphate Imbalance Drives Airway Hyperreactivity

2026-03-17

Abstract excerpt

Asthma is the most common chronic respiratory disease of childhood and is strongly associated with genetic variants at the 17q21 locus that increase expression of ORMDL3, a negative regulator of serine palmitoyl-CoA transferase (SPT), the rate-limiting enzyme in de novo sphingolipid synthesis. Reduced sphingolipid production has been linked to airway hyperreactivity, a key physiological feature of asthma, but the...

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Literature Corpus work: 77bd238a-a4d9-57cc-93d2-8d738c07925c
DOI: 10.64898/2026.03.15.26348448

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