Article
IL4 Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.
International journal of molecular sciences - 23 May 2026
Montoya-Delgado Ingrid Berenice, Ochoa-García Itzel Vianey, Escobedo-Salcedo Zaira Lorena, Ortega-Cisneros Margarita, Del Toro-Arreola Alicia, Daneri-Navarro Adrián, Valle Yeminia, Nuñez-Nuñez María Enriqueta, Bayardo-Gutierrez Beatriz, Quintero-Ramos Antonio
Abstract excerpt
Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and severity in different populations; however, their role in the Mexican population remains unclear. This study evaluated the association of IL4 promoter variants rs2243250 and...
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