Article
Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma.
American journal of respiratory and critical care medicine - 1 Sept 1999
Burchard E G, Silverman E K, Rosenwasser L J, Borish L, Yandava C, Pillari A, Weiss S T, Hasday J, Lilly C M, Ford J G, Drazen J M
Abstract excerpt
Recent family-based studies have revealed evidence for linkage of human chromosome 5q31 to the diagnosis of asthma, elevated serum IgE levels, and bronchial hyperresponsiveness. Among the candidate genes in this region is the gene encoding for human interleukin-4 (IL-4). We reasoned that this gene could also serve as a candidate gene with respect to asthma severity as indicated by the FEV(1) measured when...
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