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Article

Ceramide/sphingosine-1-phosphate imbalance is associated with distinct inflammatory phenotypes of uncontrolled asthma.

Allergy - 1 Aug 2020

Kim Seung-Hyun, Jung Hae-Won, Kim Minji, Moon Ji-Young, Ban Ga-Young, Kim Su Jung, Yoo Hyun-Ju, Park Hae-Sim

Abstract excerpt

BACKGROUND: Asthma is associated with inflammatory dysregulation, but the underlying metabolic signatures are unclear. This study aimed to classify asthma inflammatory phenotypes based on cellular and metabolic features. METHODS: To determine cellular and metabolic profiles, we assessed inflammatory cell markers using flow cytometry, sphingolipid (SL) metabolites using LC-MS/MS, and serum cytokines using ELISA....

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Asthma
Ceramides
Chromatography, Liquid
Eosinophils
Lysophospholipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tandem Mass Spectrometry

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PMID: 32072647
DOI: 10.1111/all.14236

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