Article
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Molecular psychiatry - 1 Mar 2011
Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova I N, Sawa A, Margolis R L, Cadet J L, Mori S, Vogel M W, Ross C A, Pletnikov M V
Abstract excerpt
Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders. Recent studies have shown that DISC1 has important functions in both brain development and adult brain function. We have described earlier a transgenic mouse model of inducible expression of mutant human DISC1 (hDISC1) that acts in a...
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