Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.

The Journal of cell biology - 6 Jan 2014

Zhang He, Zeitz Michael J, Wang Hong, Niu Beibei, Ge Shengfang, Li Wei, Cui Jiuwei, Wang Guanjun, Qian Guanxiang, Higgins Michael J, Fan Xianqun, Hoffman Andrew R, Hu Ji-Fan

Abstract excerpt

Kcnq1ot1 is a long noncoding ribonucleic acid (RNA; lncRNA) that participates in the regulation of genes within the Kcnq1 imprinting domain. Using a novel RNA-guided chromatin conformation capture method, we demonstrate that the 5' region of Kcnq1ot1 RNA orchestrates a long-range intrachromosomal loop between KvDMR1 and the Kcnq1 promoter that is required for maintenance of imprinting. PRC2 (polycomb repressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Cyclin-Dependent Kinase Inhibitor p57

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Silencing

Share to Genomic Imprinting

Share to KCNQ1 Potassium Channel

Share to Polycomb Repressive Complex 2

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 24395636
DOI: 10.1083/jcb.201304152
PMCID: PMC3882787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.PMID 24395636Read ↗

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Semantic proximity Read ↗

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.Semantic proximity Read ↗

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.Semantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.Semantic proximity Read ↗

Long noncoding RNA as modular scaffold of histone modification complexes.Semantic proximity Read ↗

Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.Semantic proximity Read ↗

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.Semantic proximity Read ↗

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.Semantic proximity Read ↗

The role of CTCF in the organization of the centromeric 11p15 imprinted domain interactomeSemantic proximity Read ↗

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.Semantic proximity Read ↗

Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.