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Article

Structural and functional differences in the long non-coding RNA hotair in mouse and human.

PLoS genetics - 1 May 2011

Schorderet Patrick, Duboule Denis

Abstract excerpt

Long non-coding RNAs regulate various biological processes such as dosage compensation, imprinting, and chromatin organization. HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown, in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. We looked...

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Identifiers

PMID: 21637793
DOI: 10.1371/journal.pgen.1002071
PMCID: PMC3102750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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