Article

Conserved architecture of a functional lncRNA-protein interaction in the DNA damage response pathway

2025-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Long non-coding RNA (lncRNAs) structures are emerging as key drivers in cellular functions. Unlike proteins, lncRNAs exhibit diverse patterns of conservation, reflecting the evolutionary genetic pressures they have undergone. The long intergenic non-coding RNA p21 (lincRNA-p21) is a low-conserved, mammal-specific lncRNA. It regulates the cis activation of its neighboring gene Cdkn1A, which enc...

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Literature Corpus work: b4e97a58-8775-5546-9527-576ecf86ac8c
DOI: 10.1101/2025.07.24.666508

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