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Article

VKORC1 V66M mutation in African Brazilian patients resistant to oral anticoagulant therapy.

Thrombosis research - 1 Sept 2010

Orsi Fernanda A, Annichino Bizzacchi Joyce M, de Paula Erich V, Ozelo Margareth C, Langley Michael R, Weck Karen E

Abstract excerpt

Warfarin-based anticoagulant therapy is associated with large variability in dose response. Genetic variability in the VKORC1 and CYP2C9 genes is associated with increased warfarin sensitivity. In addition, rare coding region mutations in VKORC1 have been associated with resistance to warfarin. VKORC1 and CYP2C9 variability associated with altered warfarin response is less well characterized in African and...

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Source

Identifiers

PMID: 20615525
DOI: 10.1016/j.thromres.2010.06.008

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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