Article
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 2016
Azzam Hanan, Elwakeel Hossam, Awad Ibrahim, El-Farahaty Reham, El-Gilany Abdel-Hady, El-Sharawy Solafa
Abstract excerpt
Warfarin is the most commonly prescribed anticoagulant drug; however, a narrow therapeutic range and a high risk of bleeding or stroke complicate its clinical use. Warfarin resistance was defined as prolonged warfarin requirements of more than 15 mg/day to achieve therapeutic anticoagulation or failure to achieve therapeutic anticoagulation with more than 20 mg/day. The resistance is associated with polymorphisms...
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