VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications.

doi:10.2217/pgs.10.89

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Article

VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications.

Pharmacogenomics - 1 Sept 2010

Suarez-Kurtz Guilherme, Amorim António, Damasceno Albertino, Hutz Mara H, de Moraes Manuel Odorico, Ojopi Elida B, Pena Sérgio D J, Perini Jamila A, Prata Maria João, Ribeiro-dos-Santos Andrea, Romano-Silva Marco A, Teixeira Daniel, Struchiner Claudio José

Abstract excerpt

AIMS: The heterogeneity of the Brazilian population renders the extrapolation of pharmacogenomic data derived from well-defined ethnic groups inappropriate. We investigated the influence of self-reported 'race/color', geographical origin and genetic ancestry on the distribution of four VKORC1 SNPs and haplotypes in Brazilians. Comparative data were obtained from two major ancestral roots of Brazilians: Portuguese...

Topics

Adult
Angola
Anticoagulants
Black People
Brazil
Cohort Studies
Ethnicity
Genotype
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Mozambique

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Portugal

Racial Groups

Vitamin K Epoxide Reductases

Warfarin

Source

Open in PubMed

Identifiers

PMID: 20860466
DOI: 10.2217/pgs.10.89

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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