Article
[Warfarin resistance and related pharmacogenetic information].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Nov 2008
Takahashi Harumi
Abstract excerpt
Warfarin is the mainstay of anticoagulation therapy worldwide. Its clinical use, however, is complicated by the fact that it has a narrow therapeutic index with potential bleeding complications. The dosage requirement of warfarin to produce therapeutic anticoagulation varies widely among patients. Recently genetic factors such as the CYP2C9 and VKORC1 genes have been demonstrated to be determinants of warfarin...
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