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Article

Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.

Journal of the American Heart Association - 19 Jul 2017

Jia Lixin, Zhang Wenmei, Ma Youcai, Chen Boya, Liu Yan, Piao Chunmei, Wang Yuan, Yang Min, Liu Tingting, Zhang Junmeng, Li Taotao, Nie Shaoping, Du Jie

Abstract excerpt

BACKGROUND: Cell senescence is involved in the process of organ damage and repair; however, the underlying molecular mechanism needs to be further explored. METHODS AND RESULTS: Senescence-related genes (ie, p21, p53, and ataxia telangiectasia mutated [ATM]) were shown to be elevated after myocardial infarction (MI) in both mouse and human hearts. Ten- to 12-week-old male wild-type littermates (ATM+/+) and ATM...

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Source

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Identifiers

PMID: 28724653
DOI: 10.1161/JAHA.117.006349
PMCID: PMC5586323

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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