Article
Taste function in mice with a targeted mutation of the pkd1l3 gene.
Chemical senses - 1 Sept 2010
Nelson Theodore M, Lopezjimenez Nelson D, Tessarollo Lino, Inoue Masashi, Bachmanov Alexander A, Sullivan Susan L
Abstract excerpt
Recent studies, both in vitro and in vivo, have suggested the involvement of the polycystic kidney disease-1 and -2 like genes, Pkd1l3 and Pkd2l1, in acid taste transduction. In mice, disruption of taste cells expressing PKD2L1 eliminates gustatory neural responses to acids. However, no previous data exist on taste responses in the absence of PKD1L3 or on behavioral responses in mice lacking either of these...
Topics
- Animals
- Calcium Channels
- Gene Knockout Techniques
- Gene Targeting
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- TRPP Cation Channels
- Taste