Article
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.
Nature genetics - 1 May 2001
Max M, Shanker Y G, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee R F
Abstract excerpt
The ability to taste the sweetness of carbohydrate-rich foodstuffs has a critical role in the nutritional status of humans. Although several components of bitter transduction pathways have been identified, the receptors and other sweet transduction elements remain unknown. The Sac locus in mouse, mapped to the distal end of chromosome 4 (refs. 7-9), is the major determinant of differences between sweet-sensitive...
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