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Article

Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells.

Biochemical and biophysical research communications - 2 Jul 2018

Kaneshiro Nanaka, Imaoka Ryosuke, Komai Masato, Kashiyama Taku, Sakurai Takashi, Uehara Takashi, Takasugi Nobumasa

Abstract excerpt

Amyloid-β precursor protein (APP) correlates with the pathogenesis of certain brain diseases, such as Alzheimer disease (AD). APP is cleaved by several enzymes to produce APP metabolites, including the amyloid beta peptide (Aβ), which accumulates in the brain of AD patients. However, the exact functions of APP metabolites remain elusive. In this study, using genome editing technology, we mutated juxta- and...

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Identifiers

PMID: 29777707
DOI: 10.1016/j.bbrc.2018.05.102

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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