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Article

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Stem cell reports - 11 Apr 2017

Brownjohn Philip W, Smith James, Portelius Erik, Serneels Lutgarde, Kvartsberg Hlin, De Strooper Bart, Blennow Kaj, Zetterberg Henrik, Livesey Frederick J

Abstract excerpt

Human stem cell models have the potential to provide platforms for phenotypic screens to identify candidate treatments and cellular pathways involved in the pathogenesis of neurodegenerative disorders. Amyloid precursor protein (APP) processing and the accumulation of APP-derived amyloid β (Aβ) peptides are key processes in Alzheimer's disease (AD). We designed a phenotypic small-molecule screen to identify...

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Source

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Identifiers

PMID: 28285880
DOI: 10.1016/j.stemcr.2017.02.006
PMCID: PMC5390098

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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