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Article

In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors.

Journal of neurochemistry - 1 Jun 2010

Yang Ting, Arslanova Dilyara, Xu Xiaoyin, Li Yue-Ming, Xia Weiming

Abstract excerpt

Gamma-secretase is responsible for the final cleavage of amyloid precursor protein to generate the amyloid-beta protein, the major component of plaques in the brains of Alzheimer's disease patients. gamma-Secretase inhibitors (GSI) have been explored for therapeutic inhibition of amyloid beta protein generation, but mechanistic toxicity has been documented because of its blockage of gamma-secretase cleavage of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20345767
DOI: 10.1111/j.1471-4159.2010.06681.x
PMCID: PMC4539131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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