Article
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Journal of cellular and molecular medicine - 1 Feb 2022
Weber Tobias A, Lundkvist Johan, Wanngren Johanna, Kvartsberg Hlin, Jin ShaoBo, Larssen Pia, Wu Dan, Oliveira Daniel V, Minta Karolina, Brinkmalm Gunnar, Zetterberg Henrik, Blennow Kaj, Nordvall Gunnar, Winblad Bengt, Portelius Erik, Karlström Helena
Abstract excerpt
The aggregation of β-amyloid peptide 42 results in the formation of toxic oligomers and plaques, which plays a pivotal role in Alzheimer's disease pathogenesis. Aβ42 is one of several Aβ peptides, all of Aβ30 to Aβ43 that are produced as a result of γ-secretase-mediated regulated intramembrane proteolysis of the amyloid precursor protein. γ-Secretase modulators (GSMs) represent a promising class of Aβ42-lowering...
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