Generation and regulation of beta-amyloid peptide variants by neurons.

doi:10.1046/j.1471-4159.1998.71051920.x

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Article

Generation and regulation of beta-amyloid peptide variants by neurons.

Journal of neurochemistry - 1 Nov 1998

Gouras G K, Xu H, Jovanovic J N, Buxbaum J D, Wang R, Greengard P, Relkin N R, Gandy S

Abstract excerpt

Studies of processing of the Alzheimer beta-amyloid precursor protein (betaAPP) have been performed to date mostly in continuous cell lines and indicate the existence of two principal metabolic pathways: the "beta-secretase" pathway, which generates beta-amyloid (A beta(1-40/42); approximately 4...

Topics

Amino Acid Sequence
Amyloid beta-Peptides
Animals
Cells, Cultured
Genetic Variation
Mice
Molecular Sequence Data
Molecular Weight
Neurons
Peptide Fragments
Rats
Rats, Sprague-Dawley
Tumor Cells, Cultured

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