Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation and regulation of beta-amyloid peptide variants by neurons.

Journal of neurochemistry - 1 Nov 1998

Gouras G K, Xu H, Jovanovic J N, Buxbaum J D, Wang R, Greengard P, Relkin N R, Gandy S

Abstract excerpt

Studies of processing of the Alzheimer beta-amyloid precursor protein (betaAPP) have been performed to date mostly in continuous cell lines and indicate the existence of two principal metabolic pathways: the "beta-secretase" pathway, which generates beta-amyloid (A beta(1-40/42); approximately 4 kDa), and the "alpha-secretase" pathway, which generates a smaller fragment, the "p3" peptide (A beta(17-40/42);...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cells, Cultured
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Molecular Weight

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9798916
DOI: 10.1046/j.1471-4159.1998.71051920.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation and regulation of beta-amyloid peptide variants by neurons.PMID 9798916Read ↗

Normal Cellular Processing of the β‐Amyloid Precursor Protein Results in the Secretion of the Amyloid β Peptide and Related Molecules<sup>a</sup>Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.Semantic proximity Read ↗

Mass Spectrometric Characterization of Amyloid-β Species in the 7PA2 Cell Model of Alzheimer's DiseaseSemantic proximity Read ↗

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.Semantic proximity Read ↗

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.Semantic proximity Read ↗

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypesSemantic proximity Read ↗

Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.Semantic proximity Read ↗

Amyloid β-peptide is produced by cultured cells during normal metabolism: A repriseSemantic proximity Read ↗

Amyloid-β oligomers: their production, toxicity and therapeutic inhibitionSemantic proximity Read ↗

Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells.Semantic proximity Read ↗

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.