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Article

Neuropeptide S receptor gene variation modulates anterior cingulate cortex Glx levels during CCK-4 induced panic.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2015

Ruland Tillmann, Domschke Katharina, Schütte Valerie, Zavorotnyy Maxim, Kugel Harald, Notzon Swantje, Vennewald Nadja, Ohrmann Patricia, Arolt Volker, Pfleiderer Bettina, Zwanzger Peter

Abstract excerpt

An excitatory-inhibitory neurotransmitter dysbalance has been suggested in pathogenesis of panic disorder. The neuropeptide S (NPS) system has been implicated in modulating GABA and glutamate neurotransmission in animal models and to genetically drive altered fear circuit function and an increased risk of panic disorder in humans. Probing a multi-level imaging genetic risk model of panic, in the present magnetic...

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Identifiers

PMID: 26235955
DOI: 10.1016/j.euroneuro.2015.07.011

Genes

CCK
NPS
NPSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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