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Article

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Mar 2015

Slattery David A, Naik Roshan R, Grund Thomas, Yen Yi-Chun, Sartori Simone B, Füchsl Andrea, Finger Beate C, Elfving Betina, Nordemann Uwe, Guerrini Remo, Calo Girolamo, Wegener Gregers, Mathé Aleksander A, Singewald Nicolas, Czibere Ludwig, Landgraf Rainer, Neumann Inga D

Abstract excerpt

Neuropeptide S (NPS) has generated substantial interest due to its anxiolytic and fear-attenuating effects in rodents, while a corresponding receptor polymorphism associated with increased NPS receptor (NPSR1) surface expression and efficacy has been implicated in an increased risk of panic disorder in humans. To gain insight into this paradox, we examined the NPS system in rats and mice bred for high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25788677
DOI: 10.1523/JNEUROSCI.4764-13.2015
PMCID: PMC6605130

Genes

NPS
NPSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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