Article
Quality control and quality assurance in genotypic data for genome-wide association studies.
Genetic epidemiology - 1 Sept 2010
Laurie Cathy C, Doheny Kimberly F, Mirel Daniel B, Pugh Elizabeth W, Bierut Laura J, Bhangale Tushar, Boehm Frederick, Caporaso Neil E, Cornelis Marilyn C, Edenberg Howard J, Gabriel Stacy B, Harris Emily L, Hu Frank B, Jacobs Kevin B, Kraft Peter, Landi Maria Teresa, Lumley Thomas, Manolio Teri A, McHugh Caitlin, Painter Ian, Paschall Justin, Rice John P, Rice Kenneth M, Zheng Xiuwen, Weir Bruce S
Abstract excerpt
Genome-wide scans of nucleotide variation in human subjects are providing an increasing number of replicated associations with complex disease traits. Most of the variants detected have small effects and, collectively, they account for a small fraction of the total genetic variance. Very large sa...
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