Article
reGenotyper: Detecting mislabeled samples in genetic data.
PloS one - 1 Jan 2017
Zych Konrad, Snoek Basten L, Elvin Mark, Rodriguez Miriam, Van der Velde K Joeri, Arends Danny, Westra Harm-Jan, Swertz Morris A, Poulin Gino, Kammenga Jan E, Breitling Rainer, Jansen Ritsert C, Li Yang
Abstract excerpt
In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the "ideal" genotype and identify "best-matched" labels for mislabeled samples. On average, we identified 4% of...
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