Article
Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.
Journal of occupational and environmental medicine - 1 Jul 2010
McCanlies Erin C, Yucesoy Berran, Mnatsakanova Anna, Slaven James E, Andrew Michael, Frye Bonnie L, Schuler Christine R, Kreiss Kathleen, Weston Ainsley
Abstract excerpt
OBJECTIVE: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). METHODS: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain...
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