Article
Better living with hyper-mutation.
Environmental and molecular mutagenesis - 1 Jul 2016
Goodman Myron F
Abstract excerpt
The simplest forms of mutations, base substitutions, typically have negative consequences, aside from their existential role in evolution and fitness. Hypermutations, mutations on steroids, occurring at frequencies of 10(-2) -10(-4) per base pair, straddle a domain between fitness and death, depending on the presence or absence of regulatory constraints. Two facets of hypermutation, one in Escherichia coli...
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