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Article

A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort.

AIDS (London, England) - 31 Jul 2010

Price Heather, Lacap Philip, Tuff Jeff, Wachihi Charles, Kimani Joshua, Ball Terry B, Luo Ma, Plummer Francis A

Abstract excerpt

OBJECTIVE: The innate immune component TRIM5alpha has the ability to restrict retrovirus infection in a species-specific manner. TRIM5alpha of some primate species restricts infection by HIV-1, whereas human TRIM5alpha lacks this specificity. Previous studies have suggested that certain polymorphisms in human TRIM5alpha may enhance or impair the proteins affinity for HIV-1. This study investigates the role of...

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Identifiers

PMID: 20588169
DOI: 10.1097/QAD.0b013e32833b5256
PMCID: PMC2921035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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