A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection.

doi:10.1089/AID.2012.0369

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Article

A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection.

AIDS research and human retroviruses - 1 Jun 2013

Nakayama Emi E, Nakajima Toshiaki, Kaur Gurvinder, Mimaya Jun-ich, Terunuma Hiroshi, Mehra Narinder, Kimura Akinori, Shioda Tatsuo

Abstract excerpt

TRIM5α is a factor contributing to intracellular defense mechanisms against retrovirus infection. Rhesus and cynomolgus monkey TRIM5αs potently restrict HIV-1, whereas human TRIM5α shows weak effects against HIV-1. We investigated the association between a single nucleotide polymorphism in the TRIM5α linker 2 region (rs11038628), which substituted aspartic acid (D) for glycine (G) at position 249, with...

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PMID: 23379364
DOI: 10.1089/AID.2012.0369
PMCID: PMC3696946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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