Article
TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil.
Immunologic research - 1 Dec 2016
Celerino da Silva Ronaldo, Coelho Antonio Victor Campos, Arraes Luiz Cláudio, Brandão Lucas André Cavalcanti, Crovella Sergio, Guimarães Rafael Lima
Abstract excerpt
Humans show heterogeneity in vulnerability to HIV-1 infection, partially under control of genes involved in host immunity and virus replication. TRIM5α protein has restriction activity against replication of many retroviruses. Human TRIM5 gene single nucleotide polymorphisms have been reported as involved in susceptibility to HIV-1 infection. We recruited 213 HIV-1-positive patients and 234 healthy uninfected...
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